1 27 - Hydroxycholesterol accelerates cellular senescence in human lung 1 resident cells
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چکیده
27-Hydroxycholesterol accelerates cellular senescence in human lung 1 resident cells 2 3 Yuichiro Hashimoto, Hisatoshi Sugiura, M.D., Ph.D., Shinsaku Togo, M.D., Ph.D., Akira 4 Koarai, M.D., Ph.D., Kyoko Abe, M.D., Ph.D., Mitsuhiro Yamada, M.D., Ph.D., Tomohiro 5 Ichikawa, M.D., Ph.D., Takashi Kikuchi, M.D., Ph.D., Tadahisa Numakura, M.D., 6 Katsuhiro Onodera, M.D., Rie Tanaka, M.D., Kei Sato, M.D., Satoru Yanagisawa, M.D., 7 Ph.D., Tatsuma Okazaki, M.D., Ph.D., Tsutomu Tamada, M.D., Ph.D., Toshiaki Kikuchi, 8 M.D., Ph.D., Yasushi Hoshikawa, M.D., Ph.D., Yoshinori Okada, M.D., Ph.D., Masakazu 9 Ichinose, M.D., Ph.D. 10 11 1 Department of Respiratory Medicine, Tohoku University Graduate School of 12 Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. 13 2 Department of Respiratory Medicine, Juntendo University School of Medicine, 3-1-3 Hongo, 14 Bunkyo-ku, Tokyo, 113-8431, Japan. 15 3 Third Department of Internal Medicine, Wakayama Medical University School of Medicine, 16 811-1 Kimiidera, Wakayama, 641-0012, Japan. 17 4 Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate 18 School of Medical and Dental Sciences, 1-757 Asahimachidori, Chuoku, Niigata, 951-8510, 19 Articles in PresS. Am J Physiol Lung Cell Mol Physiol (April 1, 2016). doi:10.1152/ajplung.00351.2015
منابع مشابه
27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells.
Cellular senescence is reportedly involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). We previously showed that 27-hydroxycholesterol (27-OHC) is elevated in the airways of COPD patients compared with those in healthy subjects. The aim of this study was to investigate whether lung fibroblasts of COPD patients are senescent and to determine the effects of 27-OHC on sene...
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